Interaction of Integral Membrane Proteins with Multivalent Ligands

Properties of multivalent functions associated with certain integral operator

Let A(p) denote the class of functions which are analytic in the open unit disk U. By making use of certain integral operator,we obtain some interesting properties of multivalent analytic functions.

INTERACTION OF PROTEINS WITH SMALL MOLECULES

A novel approach for the identification of protein-protein interaction with integral membrane proteins.

Protein-protein interaction plays a major role in all biological processes. The currently available genetic methods such as the two-hybrid system and the protein recruitment system are relatively limited in their ability to identify interactions with integral membrane proteins. Here we describe the development of a reverse Ras recruitment system (reverse RRS), in which the bait used encodes a m...

Stabilizing Protein-Protein-Interactions with Multivalent Ligands

Huntington’s disorder (HD) is one of the neurodegenerative disorders in which the polyglutamine (polyQ) tract of the protein huntingtin (htt) is found to be expanded. First exon of this mutant htt protein is found in the inclusions in the brain of the patient suffering from HD, which is the pathological hallmark of the disease1. Exon-1 of htt comprises of 17 amino acid long N-terminal helix (Nt...

Tuning chemotactic responses with synthetic multivalent ligands.

BACKGROUND Multivalent ligands have been used previously to investigate the role of ligand valency and receptor clustering in eliciting biological responses. Studies of multivalent ligand function, however, typically have employed divalent ligands or ligands of undefined valency. How cells respond to multivalent ligands of distinct valencies, which can cluster a signaling receptor to different ...